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Research on Hydroxyapatite Toothpaste Efficacy & Security
Biomimetic hydroxyapatite and caries prevention: a scientific evaluate and meta-analysis (2021)
Based mostly on this systematic evaluate and meta-analysis of over 291 research of micro-Hydroxyapatite, the authors concluded there’s good proof that micro-Hydroxyapatite in oral care merchandise within the absence of fluoride successfully reduces caries. They don’t conclude on how a lot micro-Hydroxyapatite is good, however this newer research (performed after this evaluate was revealed) mentions it ought to be round 10-15% for micro-Hydroxyapatite.
Dr. B’s Notes: Nice abstract of the literature about nano-hydroxyapatite, particularly the advantages of utilizing nano-hydroxyapatite for its preventive, restorative, and regenerative functions in dentistry. Gives you an concept of the vast utilization of nano-Hydroxyapatite in not solely dentistry, however a variety of functions in drugs as nicely.
Demineralized dentin infiltrated with silica NPs seems to encourage heterogeneous mineralization of the dentin collagen matrix following publicity to a synthetic saliva answer.
Reconsidering remineralization methods to incorporate nanoparticle hydroxyapatite.
This in-vitro research documented the deposition of nanoparticle hydroxyapatite on demineralized enamel surfaces after remedy with an experimental remineralization gel. This discovering helps consideration of an extra strategy to remineralization that features pH neutralization methods and nanoparticle hydroxyapatite crystals.
Impact of nano-hydroxyapatite focus on remineralization of preliminary enamel lesion in vitro (2009)
Dr. B’s notes: That is an older research out of China which studied 4 totally different concentrations of nano-hydroxyapatite (1%, 5%, 10% and 15% by weight). The ten% and 15% demonstrated efficacy (in different phrases, labored nicely) nevertheless it’s not clear what sort of nano-Hydroxyapatite was used, together with particle dimension and particle form, sadly. The essential factor to know right here is that the focus of hydroxyapatite was calculated primarily based on weight, not quantity, like toothpaste producers do. So, in actuality, the therapeutic dose is between 1 and three% if calculating by quantity.
Remineralization Potential of Nano-Hydroxyapatite on Preliminary Enamel Lesions: An in vitro Examine (2011)
Dr. B’s Notes: The remineralization impact of nano-Hydroxyapatite elevated considerably when the pH was lower than 7. Why is that this essential? You’re going to listen to lots of people say that for remineralization to happen, pH must be impartial or greater, however this incorrect; the pH should be between 5.5 and 6.5 to ensure that there to be ion trade (on this case, remineralization). The proportion of floor microhardness restoration and built-in mineral loss obtained from CSMH checks demonstrated that nano-HA gives higher remineralization than micro-HA.
Combined Results of Nano-Hydroxyapatite and NaF on Remineralization of Early Caries Lesion
The purpose of this research was to judge the mixed results of a nano-HA and fluoride mouthrinse on an early caries lesion in human enamel utilizing an in vitro cycle remineralization and remedy mannequin.
Effectiveness of nano-hydroxyapatite toothpaste in lowering dentin hypersensitivity: a double-blind randomized managed trial
A double-blind randomized medical trial that in contrast the efficacy in lowering dentin hypersensitivity of a dentifrice formulation containing nano-hydroxyapatite with a fluoride dentifrice and a placebo.
Nano-HA and NAF mouthrinses can tremendously improve remineralization and enhance tooth microhardness.
Remineralization Potential of New Toothpaste Containing Nano-Hydroxyapatite
The outcomes confirmed that there have been no important variations in Vickers Hardness Quantity values between the 2 toothpastes (P>0.05). A toothpaste containing nano-sized hydroxyapatite has the potential to remineralize an incipient caries lesion. As well as, the addition of fluoride had no synergistic impact on remineralization.
Dr. B’s Notes: This research was carried out in vitro and in vivo—you don’t see that too typically!
Comparison of hydroxyapatite and fluoride oral care gels for remineralization of preliminary caries: a pH-cycling research (2020)
Dr. B’s notes: Peer-reviewed research demonstrating 15% micro-Hydroxyapatite-based gel (15% HAP) was as efficient as fluoride-based gel (at 12,500 ppm, which is even stronger than Prevident 5000) in remineralizing preliminary caries lesion.
Enamel and dentine remineralization by nano-hydroxyapatite toothpastes
Toothpastes containing n-HAp revealed greater remineralizing results in comparison with amine fluoride toothpastes with bovine dentine, and comparable traits had been obtained for enamel.
Remineralization of early caries by a nano-hydroxyapatite dentifrice
The aim of this randomized, double-blind, crossover, in situ research was to judge the efficacy of nano-hydroxyapatite (nHAP) dentifrices on caries remineralization and demineralization inhibition. nHAP dentifrice induced remineralization akin to a fluoride dentifrice, and inhibited caries growth, thus suggesting that an nHAP dentifrice will be an efficient different to fluoride toothpaste.
Artificial Biomimetic Carbonate-Hydroxyapatite Nanocrystals for Enamel Remineralization (2008)
Dr. B’s Notes: Simply one other early research out of Italy that helps the concept nano-Hydroxyapatite is nice at remineralizing enamel.
- HApNPs allowed Ca2+ and PO43− launch in low pHs.
- HApNPs allow remineralization of caries-like enamel lesions.
This research investigated the power of hydroxyapatite nanoparticles (nano-HA) to remineralize enamel, and their impact on sealant microleakage and shear bond power (SBS).
Nano-hydroxyapatite toothpaste ingredient for enamel remineralization and sensitivity
Bionic results of nano hydroxyapatite dentifrice on demineralised floor of enamel publish orthodontic debonding: in-vivo cut up mouth research
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