I’ve been getting plenty of emails a couple of new Xyngular product referred to as GLP-X. As the corporate web site says, ‘GLP-X is a premium complement components crafted from naturally sourced elements clinically studied to extend GLP-1 manufacturing.* (notice asterisk that results in disclaimer that none of those claims have been evaluated by the FDA) It isn’t nearly managing weight—it’s about elevating your outcomes.’

As a registered dietitian, I’m all the time eager about taking a more in-depth have a look at these kinds of firms and their dietary supplements, as a result of all too typically, I discover that they sidestep the reality, and the analysis, within the curiosity of creating gross sales.

This GLP-X overview examines the claims that Xyngular and its salespeople are making about this product, what GLP-1 is, and if we will actually ‘hack’ it with food plan and dietary supplements to imitate the motion of GLP-1 agonists like Ozempic.

What’s GLP-1?

GLP-1, or glucagon-like peptide-1, is a peptide hormone that’s produced within the gut. Its job is to stimulate insulin (which brings glucose into cells, and is why GLP-1 medicine have been initially accepted as drugs for diabetes), and inhibit glucagon (glucagon will increase blood sugar and fatty acids within the blood when meals isn’t current). 

GLP-1 additionally slows down gastrointestinal motility, which makes us really feel fuller for longer. Therefore, weight reduction (and sure, unwanted effects like vomiting for some people who find themselves on GLP-1 agonist meds).

How do GLP-1 agonists like Ozempic work?

I wrote about Ozempic and different GLP-1 agonists for weight reduction right here

All of us have GLP-1 receptors in our physique. GLP-1 agonists are analog variations of our personal GLP-1 (related, however not precisely the identical), and so they work by binding to and activating our physique’s GLP-1 receptors. 

When this occurs, we see the identical results as those I described above: elevated insulin and decreased glucagon, and slowed motility with ensuing fullness. 

GLP-1 agonists have confirmed to be extraordinarily secure and efficient for weight reduction, however predictably, there are folks and firms desirous to make their very own buck by convincing others that ‘Huge Pharma’ is the enemy and that ‘pure’ GLP-1 dietary supplements are so significantly better than precise remedy.

Try this submit about Xyngular GLP-X:

The selling of Huge Pharma conspiracy theories whereas spouting the Attraction to Nature fallacy (pure is best! OMG SYNTHETIC MEDICATION!) is a traditional gross sales tactic that’s sadly changing into extra widespread, particularly amongst multi-level advertising and marketing salespeople. It’s mistaken, deceptive, and simply plain opportunistic, which is the primary purpose why, as a dietitian, I selected to write down this submit. 

Everybody ought to pay attention to this kind of factor. Oh, and in addition, this complement is NOT ‘backed by 3 scientific trials.’ Not even shut. See how MLM salespeople can mainly say something to promote product?

Horrible. Additionally: a 30 day provide of GLP-X prices $75 USD. Not precisely what I’d name ‘inexpensive.’

Can we improve our GLP-1 naturally utilizing meals and dietary supplements?

Let’s begin with the meals a part of the equation.

There are particular meals which can be recognized to extend ranges of GLP-1 in our our bodies. Excessive-fibre grains, eggs, nuts, and avocado are amongst them, in accordance with this 2016 overview.

Particularly, mono and polyunsaturated fat, proteins, and fermentable fibre (fermentation within the intestine to short-chain fatty acids will increase GLP-1 ranges) from grains, legumes, and a few fruits like apples and inexperienced bananas. Analysis on this space is fairly hit and miss although, and as common I’m reluctant to take animal research and extrapolate them to people. 

It’s secure to say that even when we eat meals that improve GLP-1 ranges in our our bodies, this doesn’t even method the effectiveness of GLP-1 agonists for weight reduction. 

Let’s take into consideration this for a second – we’ve had entry to those meals perpetually. Would we rapidly uncover that they’ve these magical weight reduction powers past what we already know?

I extremely doubt it.

My suggestions listed here are the identical as all the time: plenty of fibre, enough protein, wholesome fat. Can’t lose. 

So far as dietary supplements, as with meals, there have been none which have proven the extent of effectiveness of GLP-1 agonist drugs. 

If a complement does have related efficacy to precise GLP-1 agonist meds for weight reduction, it seemingly is not going to be offered by a multi-level advertising and marketing firm. It is going to be regulated by the FDA and used as a reliable therapy.

What’s Xyngular?

Xyngular is an MLM firm that sells diet merchandise. 

I did an up to date Xyngular overview on my web site in 2020, and I doubt a lot has modified with the corporate since then.

Right here’s a few of Xyngular’s product lineup. Typical fats burners, ‘craving controllers, and intestine well being boosters.

Most if not all diet MLM firms make use of the identical methods to make gross sales (and that is under no circumstances an exhaustive listing):

Huge claims which can be unattainable to again up

Lack of oversight of their salespeoples’ social media posts

Poor or no analysis on their merchandise

Fixed upsells

Making the most of girls who need to make an earnings

I wrote about my points with MLMs and their coaches right here, however let’s simply say that Xyngular is unremarkable amongst its MLM friends. 

What’s Xyngular GLP-X?

Xyngular GLP-X is a complement that’s being marketed as a substitute for GLP-1 agonist drugs for weight reduction and ‘GLP-1 assist.’ What’s that, anyhow? I wasn’t conscious that our GLP-1 wanted to be supported.

Made up time period with imprecise well being declare = purple flag.

It comes with all the common bells and whistles of a newly launched MLM product – full court docket press gross sales throughout social media by the Xyngular salespeople, cute little graphics that inform us mainly nothing scientific, and naturally, magical and fantastical guarantees that this little bottle incorporates the reply to all of our issues…no prescription required!

Xyngular GLP-X elements

Herbs and chromium and proprietary blends, oh my! Right here’s what GLP-X has in it:

Carb administration mix

This proprietary mix incorporates Eriomin and berberine. That is the precise mix in Xyngular GLP-X that the corporate states will increase GLP-1. 

Eriomin is a patented citrus bioflavonoid nutraceutical complement. A day by day dose (2 capsules) of GLP-X incorporates 250mg of Eriomin.

The place have I heard about Eriomin earlier than? Oh, proper! The Glucose Goddess’s subsequent complement, Anti-Spike, incorporates it as nicely. I wrote all about Anti-Spike right here, and simply to repeat what I mentioned about Eriomin in that case, there are two research about this citrus extract and blood glucose. Each are comparatively unremarkable when it comes to blood sugar discount. 

One of many research, performed in 2019, noticed a 15% rise in GLP-1 with dosages of 200-800 mg of Eriomin over 12 weeks. Nevertheless, researchers discovered it had no impact on physique weight, BMI, lean mass, fats mass, fats share, and hip waist ratio. 

The 12-week 2022 examine that includes Eriomin discovered a 17% rise in GLP-1 with 200 mg a day of the ingredient. Nevertheless, physique weight and BMI remained unchanged. 

You’ve in all probability heard me bang on and on in regards to the significance of ‘scientific relevance,’ and that is the right time to indicate you what I imply. 

Within the above research, we see that GLP-1 ranges have been certainly increased after supplementation with Eriomin. This sounds nice, till you’re wanting to make use of this ingredient to advertise weight reduction. As a result of despite the fact that there was a big change within the examine topics’ GLP-1, nothing actually occurred to their weight whereas these ranges have been elevated. 

It mainly didn’t change a factor round weight. 

Repeat after me: it might be ‘vital,’ however that doesn’t imply it’s clinically related to us!

So far as Berberine, we do know that it has constructive results for rising GLP-1 and for reducing blood glucose in folks with diabetes. Nevertheless, berberine doesn’t decrease blood glucose by rising GLP-1 within the physique; it promotes insulin secretion and improves glucose regulation, amongst different mechanisms.

Once more, scientific relevance of this ingredient for GLP-1-related weight reduction? Most likely none. 

GLP-X additionally incorporates a proprietary ‘water stability mix,’ in any other case generally known as a diuretic. Peeing out fluids doesn’t equal ‘weight reduction.’ Or, ought to I say, ‘fats loss.’ 

Then there’s the proprietary ‘urge for food assist mix,’ which incorporates the standard suspects: inexperienced espresso bean, 5-ATP, and phytosterols, none of which have ever been confirmed to facilitate vital weight reduction in people.

Even so, a ton of multi-level marketed merchandise proceed to place these elements of their weight reduction merchandise. Sadly, science doesn’t care how onerous you want for one thing to work so your product could be the ‘subsequent neatest thing.’

A phrase about proprietary blends: I like to recommend not buying merchandise that comprise proprietary blends. These are mainly smokescreens that firms can conceal behind in order that they don’t need to reveal the precise quantities of elements which can be of their merchandise. It may very well be a bit of, it may very well be loads. It may very well be the efficient dose (assuming any of the elements are efficient in any respect), it may very well be much less. For GLP-X, for instance, we do not know how a lot Berberine or Eriomin is in every capsule. It’s a roulette wheel that I don’t advocate spinning along with your pockets or your well being.

GLP-X has two extra elements which can be equally underwhelming for weight reduction and results on GLP-1: chromium and magnesium.

Nothing about these two minerals will increase weight reduction or GLP-1. That’s all.

What? However I believed GLP-X is ‘backed by 3 scientific trials’?

The truth that Xyngular and its salespeople can say that the elements on this product are ‘clinically studied to extend GLP-1’ makes most individuals suppose that 1. GLP-X itself has constructive research behind it (it doesn’t) and a couple of. the elements ship clinically related and significant outcomes for GLP-1 resulting in weight reduction. 

Nope to all of that, but it surely’s a advertising and marketing tactic I see actually every single day with dietary supplements. It’s deceptive and it’s disappointing. 

Does Xyngular GLP-X work?

Whereas a number of the elements in Xyngular GLP-X have been proven to enhance blood glucose administration in some folks, there isn’t a analysis to indicate that the GLP-X complement itself truly does what Xyngular claims it does.

There are many GLP-X testimonials, however these are simply faked, and guess what? MLM coaches like to submit them, however conveniently neglect to submit the not-so-glowing evaluations, too.

Why are we so determined to look a sure manner, that we belief our well being to those firms and their salespeople, most of whom have zero related well being coaching and who don’t care about our well being, solely their gross sales? Please don’t.

So far as ‘pure’ GLP-1 dietary supplements, these are extra delusion than reality. Simply because one thing will increase our GLP-1 ranges doesn’t imply that this results in the burden loss results we’d see with GLP-1 agonist drugs. In reality, the analysis is fairly clear that in most (if not all) instances, it doesn’t.

Save your $75.